You can create a new channel via the database context menu
 
Database
→ New channel
→ CAN
 

Or directly import your communication matrix

Let CanEasy detect all connected bus adapters via the context menu of the hardware entry
 

  Hardware

  → Refresh

Connect the database channel via Drag & Drop with the hardware  channel

Start the simulation to initialize your bus adapter

After simulation start CAN frames can be sent and received

Create a new trace via the context menu of the “Trace panel”

Using a trace you can see whether messages are sent or received on the bus

To see unknown messages you need to activate this in the toolbar

To get the interpretation of the received message simply import the communication matrix into the database channel

Select
Import → DBC file
from channels context menu

Start simulation

To change signal values, you can open CanPanels with a double click or via  the context menu

CanPanels can be opened for a complete ECU or single messages

When changing the signal value in the CanPanel, you can see the change in the trace panel